Stem Cells International

Epigenetic Regulation Shapes the Stem Cells State


Status
Published

1University of Milan, Milan, Italy

2IRCCS Fondazione Santa Lucia, Rome, Italy

3National Institutes of Health, Bethesda, USA

4National Research Council (CNR), Rome, Italy

5The University of Melbourne, Melbourne, Australia


Epigenetic Regulation Shapes the Stem Cells State

Description

Genetic studies in different model organisms have provided compelling evidence for the importance of chromatin regulators in fundamental developmental transitions, including the formation of the three germ layers in gastrulation as well as during terminal differentiation and regenerative events occurring in postnatal life.

Establishment and maintenance of lineage commitment of stem cells is orchestrated by epigenetic factors, such as histone modifications, regulatory RNAs, chromatin remodeling enzymes, and DNA methylation. These factors act to translate extracellular signals into novel and stable patterns of gene expression. In response to signals from the external niche and/or intracellular signaling pathways, embryonic and adult stem cells engage epigenetic factors in the transition process towards differentiation. This transition is accompanied by global changes in the nuclear organization of the genomic information and a significant remodeling of the epigenome, as depicted by recent genome-wide studies.

In contrast to genetic changes to the DNA sequence, epigenetic modifications are reversible and are, therefore, considered as promising therapeutic targets for the use of stem cells in the treatment of human diseases.

We invite investigators to contribute original research articles as well as review articles addressing the role of epigenetics in regulating cellular processes such as stem cell identity and lineage commitment, reprogramming, and tissue regeneration.

Potential topics include, but are not limited to:

  • Chromatin enzymes and histone modifications involved in the maintenance of pluripotency and differentiation of stem cells
  • Long and short regulatory RNAs as modulators of stem cells identity and differentiation
  • Alterations of nuclear structure and genome architecture during stem cells transitions
  • Role of histone variants and chromatin remodelers in modulating the epigenetic landscape of stem cells
  • Epigenetic factors as therapeutic targets to modulate the stem cells state

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 8143407
  • - Editorial

Epigenetic Regulation Shapes the Stem Cells State

Giuseppina Caretti | Libera Berghella | ... | James Ryall
  • Special Issue
  • - Volume 2016
  • - Article ID 5725927
  • - Review Article

DNA Methylation in Skeletal Muscle Stem Cell Specification, Proliferation, and Differentiation

Rhianna C. Laker | James G. Ryall
  • Special Issue
  • - Volume 2016
  • - Article ID 1816525
  • - Review Article

Metaboloepigenetic Regulation of Pluripotent Stem Cells

Alexandra J. Harvey | Joy Rathjen | David K. Gardner
  • Special Issue
  • - Volume 2016
  • - Article ID 6093601
  • - Review Article

Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies

Silvia Consalvi | Martina Sandoná | Valentina Saccone
  • Special Issue
  • - Volume 2016
  • - Article ID 8652748
  • - Review Article

Integration of Signaling Pathways with the Epigenetic Machinery in the Maintenance of Stem Cells

Luca Fagnocchi | Stefania Mazzoleni | Alessio Zippo
  • Special Issue
  • - Volume 2016
  • - Article ID 4304916
  • - Research Article

Direct Reprogramming of Mouse Fibroblasts to Neural Stem Cells by Small Molecules

Yan-Chuang Han | Yoon Lim | ... | Xin-Fu Zhou
  • Special Issue
  • - Volume 2016
  • - Article ID 3162363
  • - Research Article

Dynamic Changes in Occupancy of Histone Variant H2A.Z during Induced Somatic Cell Reprogramming

Fulu Dong | Zhenwei Song | ... | Honglin Liu
  • Special Issue
  • - Volume 2016
  • - Article ID 9464591
  • - Review Article

Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based Models

Rubén Fernández-Santiago | Mario Ezquerra
  • Special Issue
  • - Volume 2016
  • - Article ID 1797692
  • - Review Article

Long Noncoding RNA Regulation of Pluripotency

Alessandro Rosa | Monica Ballarino
  • Special Issue
  • - Volume 2016
  • - Article ID 4969430
  • - Research Article

Cardiac Niche Influences the Direct Reprogramming of Canine Fibroblasts into Cardiomyocyte-Like Cells

Giacomo Palazzolo | Mattia Quattrocelli | ... | Maurilio Sampaolesi
Stem Cells International
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Acceptance rate44%
Submission to final decision76 days
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CiteScore7.200
Impact Factor3.869
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