Homeostatic Imbalance in Epithelial Ducts and Its Role in Carcinogenesis
Emergence of polarized cells during normal epithelium development. (a) Sequence of consecutive stages in the development of normal epithelium from a single cell to a one layer of polarized cells enclosing the hollow lumen. (b). Distributions of membrane receptors in each polarized cell forming the final one-layered epithelial structure. Cell membrane receptors are color-coded identically in (a) and (b). The red bands surrounding the multicellular structures in (a) represent accumulation of ECM proteins.