Table of Contents Author Guidelines Submit a Manuscript
Scientifica
Volume 2012, Article ID 132978, 8 pages
http://dx.doi.org/10.6064/2012/132978
Research Article

Homeostatic Imbalance in Epithelial Ducts and Its Role in Carcinogenesis

1Depatment of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Room SRB-4 24000G, Tampa, FL 33612, USA
2Department of Oncologic Sciences, College of Medicine, University of South Florida, Tampa, FL 33612, USA

Received 31 May 2012; Accepted 25 June 2012

Academic Editors: P. Bates and M. Mottolese

Copyright © 2012 Katarzyna A. Rejniak. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. C. Dufort, M. J. Paszek, and V. M. Weaver, “Balancing forces: architectural control of mechanotransduction,” Nature Reviews Molecular Cell Biology, vol. 12, no. 5, pp. 308–319, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. J. I. Lopez, I. Kang, W. You, D. M. McDonald, and V. M. Weaver, “In situ force mapping of mammary gland transformation,” Integrative Biology, vol. 3, pp. 910–921, 2011. View at Google Scholar
  3. H. Huang, R. D. Kamm, and R. T. Lee, “Cell mechanics and mechanotransduction: pathways, probes, and physiology,” American Journal of Physiology, vol. 287, no. 1, pp. C1–C11, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. K. S. Kolahi and M. R. K. Mofrad, “Mechanotransduction: a major regulator of homeostasis and development,” Wiley Interdisciplinary Reviews: Systems Biology and Medicine, vol. 2, no. 6, pp. 625–639, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. D. E. Jaalouk and J. Lammerding, “Mechanotransduction gone awry,” Nature Reviews Molecular Cell Biology, vol. 10, no. 1, pp. 63–73, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Kitano, “Cancer robustness: tumour tactics,” Nature, vol. 426, no. 6963, p. 125, 2003. View at Google Scholar · View at Scopus
  7. J. Debnath and J. S. Brugge, “Modelling glandular epithelial cancers in three-dimensional cultures,” Nature Reviews Cancer, vol. 5, no. 9, pp. 675–688, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. M. J. Bissell, D. C. Radisky, A. Rizki, V. M. Weaver, and O. W. Petersen, “The organizing principle: microenvironmental influences in the normal and malignant breast,” Differentiation, vol. 70, no. 9-10, pp. 537–546, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. P. Lu, V. N. Weaver, and Z. Werb, “The extracellular matrix: a dynamic niche in cancer progression,” The Journal of Cell Biology, vol. 196, pp. 395–406, 2012. View at Google Scholar
  10. K. A. Rejniak and A. Anderson, “A computational study of the development of epithelial acini. I. Sufficient conditions for the formation of a hollow structure,” Bulletin of Mathematical Biology, vol. 70, no. 3, pp. 677–712, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. K. A. Rejniak and A. Anderson, “A computational study of the development of epithelial acini. II. Necessary conditions for structure and lumen stability,” Bulletin of Mathematical Biology, vol. 70, no. 5, pp. 1450–1479, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. M. J. Reginato and S. K. Muthuswamy, “Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis,” Journal of Mammary Gland Biology and Neoplasia, vol. 11, no. 3-4, pp. 205–211, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. A. A. Mailleux, M. Overholtzer, and J. S. Brugge, “Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models,” Cell Cycle, vol. 7, no. 1, pp. 57–62, 2008. View at Google Scholar · View at Scopus
  14. D. M. Bryant and K. E. Mostov, “From cells to organs: building polarized tissue,” Nature Reviews Molecular Cell Biology, vol. 9, no. 11, pp. 887–901, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Debnath, S. K. Muthuswamy, and J. S. Brugge, “Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures,” Methods, vol. 30, no. 3, pp. 256–268, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. C. M. Nelson and M. J. Bissell, “Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation,” Seminars in Cancer Biology, vol. 15, no. 5, pp. 342–352, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. D. R. Tyson, J. Inokuchi, T. Tsunoda, A. Lau, and D. K. Ornstein, “Culture requirements of prostatic epithelial cell lines for acinar morphogenesis and lumen formation in vitro: role of extracellular calcium,” Prostate, vol. 67, no. 15, pp. 1601–1613, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. F. Xu, J. Celli, I. Rizvi, S. Moon, T. Hasan, and U. Demirci, “A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform,” Biotechnology Journal, vol. 6, no. 2, pp. 204–212, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. D. J. Ferguson, “An ultrastructural study of mitosis and cytokinesis in normal “resting” human breast,” Cell and Tissue Research, vol. 252, no. 3, pp. 581–587, 1988. View at Google Scholar · View at Scopus
  20. L. E. O'Brien, M. M. P. Zegers, and K. E. Mostov, “Building epithelial architecture: Insights from three-dimensional culture models,” Nature Reviews Molecular Cell Biology, vol. 3, no. 7, pp. 531–537, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. V. Quaranta, K. A. Rejniak, P. Gerlee, and A. Anderson, “Invasion emerges from cancer cell adaptation to competitive microenvironments: quantitative predictions from multiscale mathematical models,” Seminars in Cancer Biology, vol. 18, no. 5, pp. 338–348, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. D. T. Butcher, T. Alliston, and V. M. Weaver, “A tense situation: forcing tumour progression,” Nature Reviews Cancer, vol. 9, no. 2, pp. 108–122, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. C. T. Leung and J. S. Brugge, “Outgrowth of single oncogene-expressing cells from suppressive epithelial environments,” Nature, vol. 482, pp. 410–414, 2012. View at Google Scholar
  24. J. Harunaga, J. C. Hsu, and K. M. Yamada, “Dynamics of salivary gland morphogenesis,” Journal of Dental Research, vol. 90, pp. 1070–1077, 2011. View at Google Scholar
  25. J. Debnath, K. R. Mills, N. L. Collins, M. J. Reginato, S. K. Muthuswamy, and J. S. Brugge, “The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini,” Cell, vol. 111, no. 1, pp. 29–40, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. A. E. Rodriguez-Fraticelli, S. Vergarajauregui, D. J. Eastburn et al., “The Cdc42 GEF intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis,” Journal of Cell Biology, vol. 189, no. 4, pp. 725–738, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. D. J. P. Ferguson and T. J. Anderson, “Morphological evaluation of cell turnover in relation to the menstrual cycle in the “resting” human breast,” British Journal of Cancer, vol. 44, no. 2, pp. 177–181, 1981. View at Google Scholar · View at Scopus
  28. C. J. Watson, “Involution: apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ,” Breast Cancer Research, vol. 8, no. 2, pp. 203–207, 2006. View at Google Scholar
  29. B. Mintz and K. Illmensee, “Normal genetically mosaic mice produced from malignant teratocarcinoma cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 72, no. 9, pp. 3585–3589, 1975. View at Google Scholar · View at Scopus
  30. V. M. Weaver, S. Lelièvre, J. N. Lakins et al., “β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium,” Cancer Cell, vol. 2, no. 3, pp. 205–216, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. K. A. Rejniak, “An immersed boundary framework for modelling the growth of individual cells: an application to the early tumour development,” Journal of Theoretical Biology, vol. 247, no. 1, pp. 186–204, 2007. View at Publisher · View at Google Scholar · View at Scopus