Pathology-Dependent Effects Linked to Small Heat Shock Proteins Expression: An Update
Figure 1
Small Hsps. (a) Organization of human HspB1 (Hsp27) and HspB5 (αB-crystallin) protein sequences. N-terminal gray box: WD/EPF domain; N-terminal white box: conserved sequence; black box: alpha crystallin domain; C-terminal gray box: IXI/V motif; the C-terminal flexible domain is also indicated. P: phosphorylated serine residues. Amino acids number is indicated. (b) Description of the members of the human small heat shock family of proteins. The distant Hsp16.2 polypeptide contains only a fraction of the alpha-crystallin domain. Chaperone activity and inducibility by heat shock are indicated. (c) Tissue-specific expression of constitutive small Hsps (compilation of murine as well as some human data).
