Plasma Membrane Transporters in Modern Liver Pharmacology

Table 4

Identified potential substrates of canalicular forms of ABC proteins with pharmacological interest.

	MDR1	MRP2	BCRP
Substrates	Actinomycin D	Acetaminophen-glucuronide	Abacavir
	Amitriptyline	Acetaminophen-sulphate	Aflatoxin B
	Amsacrine	p-Aminohippurate	Albendazole sulfoxide
	Bisantrene	Arsenic-glutathione	Bile acids
	Camptothecins	Bilirubin-glucuronide	Ciprofloxacin
	Cerivastatin	BQ-123	Coumestrol
	Colchicine	Diclofenac-glucuronide	Daidzein
	Cyclosporine A	S-(2,4-Dinitrophenyl)-glutathione	Dantrolene
	Daunorubicin	Estradiol-17β-glucuronide	DHEA sulphate
	Digoxin	Ethacrynic acid-glutathione	Dipyridamole
	Diltiazem	Ethinylestradiol glucuronide	Edaravone sulphate
	Docetaxel	4-Hydroxynonenal-glutathione	Enrofloxacin
	Domperidone	Indinavir	Erlotinib
	Doxorubicin	Leukotriene C4	Estradiol-17β-glucuronide
	Erlotinib	Methotrexate	Estrone-3-sulphate
	Erythromycin	Morphine-3-glucuronide	Etoposide
	Etoposide	Ochratoxin A	Furosemide
	Fexofenadine	Oxidized/reduced glutathione	Gefitinib
	Imatinib	PhIP	Genistein
	Indinavir	Ritonavir	Glyburide
	Ivermectin	Saquinavir	Grepafloxacin
	Lapatinib	Sulfotaurolithocholic acid	Hematoporphyrin
	Loperamide	Taurocholic acid	Hoechst
	Losartan	Taurolithocholate sulphate	Hydrochlorothiazide
	Lovastatin	Vinblastine	Imatinib
	Methotrexate	Vincristine	Lamivudine
	Mitoxantrone		Lapatinib
	Nelfinavir		Methotrexate
	Ondansetron		Mitoxantrone
	Oseltamivir		Nitrofurantoin
	Paclitaxel		Norfloxacin
	Phenytoin		Ofloxacin
	Prazosin		Oxfendazole
	Quinidine		Pheophorbide A
	Ritonavir		PhIP
	Saquinavir		Prazosin
	Sparfloxacin		Resveratrol 3-sulphate
	Tamoxifen		Resveratrol di-sulphate
	Terfenadine		Riboflavin
	Tetracycline		Rosuvastatin
	(99m)Tc-Tetrofosmin		Triamterene
	Topotecan		Ulifloxacin
	Vecuronium		Zidovudine
	Verapamil
	Vinblastine
	Vincristine