Schematic representation of oriP and the EBNA1 protein. (a) Organization of the oriP DS and FR elements showing genome nucleotide coordinates and EBNA1 binding sites (blue boxes). For the DS element, the positions of the four EBNA1-binding sites (numbered blue boxes), 65 bp dyad symmetry sequence (broken arrows), and nonamer repeats (solid arrows) are indicated. (b) Organization of the EBNA1 protein showing the two Gly-Arg-rich regions (red), Gly-Ala repeat (green), USP7-binding site (blue), and DNA binding and dimerization domain (black). Amino acids numbers are indicated below.
