Scientifica

Clinical Study

In Search of an Accurate Evaluation of Intrahepatic Cholestasis of Pregnancy

Table 2

Comparison of TSBA levels and serum bile acid profiles in all of the groups studied.
Normocholanaemic pregnant women ( š‘› = 2 3 )AHP ( š‘› = 1 5 )ICP low pruritus score ( š‘› = 9 )ICP high pruritus score ( š‘› = 2 3 )ICP high pruritus score treated with UDCA ( š‘› = 2 3 )
TSBA (Ī¼M) 5 . 8 Ā± 0 . 7 1 9 . 4 Ā± 2 . 0 Ā§ Ā§ 2 4 . 2 Ā± 8 . 3 5 4 . 9 Ā± 1 2 . 2 Ā§ Ā§ 4 7 . 6 Ā± 1 1 . 9 Ā§ Ā§
UDCA (Ī¼M) 3 . 1 Ā± 0 . 7 1 0 . 8 Ā± 1 . 4 Ā§ Ā§ 1 . 1 Ā± 0 . 5 5 . 2 Ā± 2 . 8 2 8 . 3 Ā± 6 . 3 Ā§ Ā§ , a
LCA (Ī¼M) 0 . 3 4 Ā± 0 . 0 6 0 . 6 0 Ā± 0 . 2 8 6 . 5 Ā± 3 . 6 Ā§ 2 0 . 3 Ā± 5 . 6 Ā§ Ā§ 2 . 2 Ā± 1 . 0 āˆ— , a
CDCA (Ī¼M) 0 . 7 5 Ā± 0 . 2 4 1 . 3 Ā± 0 . 7 1 . 8 Ā± 1 . 0 1 0 . 4 Ā± 4 . 0 ** 8 . 8 Ā± 5 . 6
CA (Ī¼M) 0 . 4 0 Ā± 0 . 1 7 1 . 1 Ā± 0 . 5 8 . 8 Ā± 5 . 2 ** 7 . 1 Ā± 2 . 3 Ā§ 5 . 7 Ā± 1 . 9 Ā§
DCA (Ī¼M) 1 . 9 Ā± 0 . 6 5 . 6 Ā± 1 . 6 Ā§ 6 . 0 Ā± 4 . 3 * 1 2 . 0 Ā± 4 . 6 Ā§ 2 . 7 Ā± 1 . 3 Ā§ , b
CA/CDCA 1 . 8 Ā± 0 . 9 5 . 5 Ā± 2 . 7 7 . 7 Ā± 3 . 9 1 8 . 5 Ā± 1 0 . 9 1 3 . 7 Ā± 7 . 5
UDCA/LCA ratio 1 1 . 1 Ā± 2 . 9 4 1 . 5 Ā± 7 . 5 Ā§ 0 . 6 5 Ā± 0 . 2 3 Ā§ 0 . 5 9 Ā± 1 . 4 Ā§ Ā§ 7 9 . 9 Ā± 2 8 . 8 āˆ— āˆ— , a
Results are expressed as means Ā± SEM. Bile acids are expressed in their free, glycine, and taurine forms. * š‘ƒ < 0 . 0 5 ** š‘ƒ < 0 . 0 1 , Ā§ š‘ƒ < 0 . 0 0 1 and Ā§ Ā§ š‘ƒ < 0 . 0 0 0 1 , with respect to normocholanaemic pregnant women. a š‘ƒ < 0 . 0 0 0 1 and b š‘ƒ < 0 . 0 5 with respect to ICP high pruritus score.