Review Article

New Prospective for the Management of Low-Risk Pulmonary Embolism: Prognostic Assessment, Early Discharge, and Single-Drug Therapy with New Oral Anticoagulants

Table 4

Ongoing phase III trials on acute treatment of pulmonary embolism.

StudyPatientsInterventionComparison

AMPLIFYAcute symptomatic VTEApixaban: 10 mg bid for 7 days then 5 mg bid Enoxaparin and dose-adjusted warfarin (INR 2.0 to 3.0)
HOKUSAI-VTEAcute symptomatic VTE, who were initially given parenteral anticoagulation therapyEdoxaban 60 mg once dailyDose-adjusted warfarin (INR 2.0 to 3.0)

VTE: venous thromboembolism.