Marsupial Genome Sequences: Providing Insight into Evolution and Disease
MHC organisation. (a) A comparison of MHC organisation across different vertebrate lineages. The organisation of the opossum MHC resembles the ancestral organisation observed in frog and chicken, and the organisation in human and mouse is derived (modified from ). (b) The tammar wallaby core MHC region is substantially different to that of the opossum, with Class II genes on either side of the Class III region and Class I genes distributed on different chromosomes.