The Association between COMT, BDNF, and NRG1 and Premorbid Social Functioning in Patients with Psychosis, Their Relatives, and Controls

Table 1

Demographics, scale scores, and genotype frequencies.

	Patients	Relatives	Controls	Total
Age (years)
N	177	86	116	379
Mean	32.8	33.4	36.3	34.0
SD	7.9	8.5	11.0	9.2
Minimum	17.0	18.0	19.0	17.0
Maximum	55.0	56.0	62.2	62.2
Sex
% females	30.5	47.7	66.4	45.4
PSA1 scores at 5–11 years
N	168	83	101	352
Mean	11.7	9.5	8.0	10.1
SD	4.5	3.4	1.8	4.0
Minimum	5.5	6.0	3.0	3.0
Maximum	26.0	24.5	12.0	26.0
PSA2 scores at 12–16 years
N	168	83	100	351
Mean	12.5	9.8	7.9	10.5
SD	5.4	4.0	2.5	4.8
Minimum	5.5	4.5	2.5	2.5
Maximum	30.0	25.5	17.0	30.0
Total PSST score
N	175	85	113	373
Mean	11.5	9.7	9.2	10.4
SD	3.4	2.5	1.6	3.0
Minimum	8.0	8.0	8.0	8.0
Maximum	26.0	19.0	15.0	26.0
NRG1
CC	15	10	10	35
TC	78	43	48	169
TT	65	24	52	141
COMT
Met/Met	41	19	34	94
Val/Met	84	38	45	167
Val/Val	47	24	31	102
BDNF
Met/Met	4	1	2	7
Val/Met	47	22	36	105
Val/Val	120	60	75	255