Histopathology of Pseudoxanthoma Elasticum and Related Disorders: Histological Hallmarks and Diagnostic Clues

<table>Histopathology of the murine PXE model using Alizarin Red and von Kossa staining with extensive mineralization in the connective tissue sheet of the whiskers (a, asterisk, <svg height="8.7875004" id="M1" style="vertical-align:-0.3135pt" version="1.1" viewbox="0 0 10.125 8.7875004" width="10.125" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.016,0,0,-.016,.062,8.325)"><path d="M528 54l-36 -38l-198 201l-198 -201l-36 38l197 200l-197 201l36 38l198 -202l198 202l36 -38l-197 -201z" id="xD7"></path></g>
</svg>20 and mineralization of Bruch’s Membrane of the eye (b arrowed, c asterisk, <svg height="8.7875004" id="M2" style="vertical-align:-0.3135pt" version="1.1" viewbox="0 0 10.125 8.7875004" width="10.125" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.016,0,0,-.016,.062,8.325)"><path d="M528 54l-36 -38l-198 201l-198 -201l-36 38l197 200l-197 201l36 38l198 -202l198 202l36 -38l-197 -201z" id="xD7"></path></g>
</svg>10 and <svg height="8.7875004" id="M3" style="vertical-align:-0.3135pt" version="1.1" viewbox="0 0 10.125 8.7875004" width="10.125" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.016,0,0,-.016,.062,8.325)"><path d="M528 54l-36 -38l-198 201l-198 -201l-36 38l197 200l-197 201l36 38l198 -202l198 202l36 -38l-197 -201z" id="xD7"></path></g>
</svg>20).</table>

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Figure 4

Figure 4: Histopathology of Pseudoxanthoma Elasticum and Related Disorders: Histological Hallmarks and Diagnostic Clues 