The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response

Table 1

Examples of small molecules—dual activators of transcription factors NRF2 and HSF1.

Compound name	Chemical structure	References
4-Hydroxy-2-nonenal		[71–74]
10-Nitro-oleic acid		[75, 76]
15-Deoxy-Δ^12,14-prostaglandin J2		[73, 74, 76–79]
Acrolein		[71, 80]
H2O2		[4, 81–83]
Celastrol		[73, 84–87]
Sulforaphane		[76, 78, 88–91]
Phenethyl isothiocyanate		[92]
Sulfoxythiocarbamate alkyl		[86, 93]
Withaferin A		[94, 95]
Curcumin		[96–108]
Bis(2-hydroxy-benzylidene)acetone		[86, 109]
Gedunin		[94, 110–113]
Diamide		[73, 114]
tBHQ (and related; oxidizable diphenols)		[20, 71, 76, 78, 81, 88, 115–119]
Sodium arsenite		[4, 71, 120–127]
1,2-Dithiole-3-thione		[39–41, 43, 128]
Heavy metals		[4, 71, 73, 76, 129–133]