Review Article
Clinical Pharmacology in Old Persons
Table 2
Clinically relevant drug interactions with St. John’s wort [
7].
| Drug | Effect of interaction with St. John’s wort |
| Amitriptyline | Steady-state concentration decreased by 22% | Cyclosporine | Steady-state concentration decreased by 52% | Digoxin | Steady-state concentration decreased by 25% | Simvastatin | AUC decreased by 50% | Tacrolimus | Steady-state concentration decreased by 80% | Theophylline | Steady-state concentration decreased by 50% | VKAs | INR 50% lower |
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AUC: area under plasma concentration time curve.
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