Clinical Pharmacology in Old Persons

Table 2

Clinically relevant drug interactions with St. John’s wort [7].

Drug	Effect of interaction with St. John’s wort
Amitriptyline	Steady-state concentration decreased by 22%
Cyclosporine	Steady-state concentration decreased by 52%
Digoxin	Steady-state concentration decreased by 25%
Simvastatin	AUC decreased by 50%
Tacrolimus	Steady-state concentration decreased by 80%
Theophylline	Steady-state concentration decreased by 50%
VKAs	INR 50% lower

AUC: area under plasma concentration time curve.