Clinical Pharmacology in Old Persons

Table 7

Conditions with (relatively) contraindicated drugs [10, 11].

Disease or problem	Contraindicated drugs
COPD	Long acting benzodiazepines, non-selective beta-receptor blocking drugs (e.g., propranolol, carvedilol, labetalol, sotalol)
Dementia	Strong acting anticholinergic agents^1
Heart failure	Verapamil, diltiazem, short acting nifedipine, NSAIDs, rosiglitazone
Lower Urinary Tract Syndrome	Anticholinergic agents^1
Active peptic ulcer disease, reflux oesophagitis, or gastritis/duodenitis	NSAIDs
Narrow angle glaucoma	Strong acting anticholinergic agents^1
Constipation	Verapamil, diltiazem, anticholinergic agents^1
Postural hypotension	Tricyclic antidepressants
Parkinson’s disease	Metoclopramide, all antipsychotics except clozapine and quetiapine
Hyponatremia (SIADH)	SSRIs
Falls	Psychoactive drugs

1Strong acting anticholinergic drugs: spasmolytics, tricyclic antidepressants, and anticholinergic antiparkinsonic drugs.