(a) Original magnification 160X. Fibrolamellar carcinomas are composed of large eosinophilic tumor cells with large vesiculated nuclei and large red nucleoli. (b) Original magnification 100X. Intratumoral fibrosis is a typical finding in fibrolamellar carcinoma. (c) Original magnification 160X. When FLC tumors grow in cell culture, they retain their large nucleoli and abundant cytoplasm. The nucleolus is often split into several larger subunits. (d) Original magnification 160X. Pale bodies are seen as large cytoplasmic inclusions with distinct borders and typically a “pale” grey color.
