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Target function, based on brown fat function in the knock out | Effect on brown adipose tissue | Effect of white adipose tissue | Phenotype | Primary mechanism | Reference |
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Inhibitory |
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Bone morphogenetic protein (BMP8B) knockout | Normal but reduced thermogenic activity, most apparent during cold exposure | Not examined | Lower body temperature, increased body mass, and an adaptation amplified with consumption of an HFD | Modulates SNS activity within BAT | [22] |
Scaffold protein p62, adipocyte specific knockout | Reduced activity and responsiveness to norepinephrine | Reduced UCP1 within inguinal | Increased body weight and fat mass and an adaptation reduced when fed an HFD | Acts specifically on mitochondrial function in brown adipocytes and thus thermogenesis | [23] |
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Stimulatory |
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Phosphatase and tensin homolog, conditional knockdown | Increased adipocyte cell size | Increased adipocyte cell size | Despite similar body mass, WAT distribution disorder is apparent | Both brown and white cells may have Myf5+ origins | [24] |
SERTA domain containing 2 (TRIP-Br2) knock out | Increased thermogenic activity and cold responsiveness | Decreased adipocyte cell size | Improved glucose homeostasis and ability to maintain body temperature during cold exposure | Modulates fat storage through inhibition of lipolysis, thermogenesis, and oxidative metabolism | [25] |
Retinaldehyde dehydrogenase 1a, knockout | None | Increased UCP1 with a greater response in perigonadal compared with inguinal | Improved glucose homeostasis and ability to maintain body temperature during cold exposure | Inhibits the browning of WAT | [26] |
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