Laboratory Diagnosis of Invasive Aspergillosis: From Diagnosis to Prediction of Outcome

Table 3

Diagnostic accuracy of the main laboratory markers for IA.

Reference	Method	Sample	Sensitivity^a	Specificity^a	DOR^b
Mengoli et al. 2009 [183]	PCR (1)	Blood	0.88 (0.75–0.94)	0.75 (0.63–0.84)	22.11 (7.77–62.92)
Mengoli et al. 2009 [183]	PCR (2)	Blood	0.75 (0.54–0.88)	0.87 (0.79–0.93)	21.33 (6.86–46.63)
Leeflang et al. 2008 [180]	GM	Blood	0.79 (0.61–0.93)	0.82 (0.71–0.83)	17.10^c
Sun et al. 2010 [182]	GM	Blood	0.66 (0.61–0.70)	0.9 (0.89–0.90)	19.1 (12.67–28.79)
Guo et al. 2010 [184]	GM	BAL	0.86 (0.70–0.94)	0.89 (0.85–0.92)	51.0^c
Onishi et al. 2012 [185]	BDG	Blood	0.77 (0.71–0.82)	0.83 (0.82–0.84)	23.2 (9.9–54.4)

aSensitivity and specificity as proportions with 95% confidence intervals (CI) given in brackets, ^bDOR diagnostic odds ratio, ^ccalculated from sensitivity and specificity data in the references, 95% CI not calculable.