Modeling to Optimize Terminal Stem Cell Differentiation

Figure 4

This theoretical curve fitting graph reveals the type of data that would come from plotting the number of cells that have differentiated over time. Data like those found in Figure 3 could be used to generate a graph such as this. Because differentiation is regulated by inductive signals, we predict it is modeled by a logistic curve; the lag period caused by upregulation of signals, the growth period caused by high signaling activity, and plateau caused by downregulation of signals.