Review Article

Genetics of Proteasome Diseases

Figure 12

Alignment of human PSME subunits 1–3. Protein sequences of the three proteasome PSME subunits were aligned using Clustal W. , identical residue in all six subunits;  :, conserved amino acids with strongly similar properties;  ., conservation between residues of weakly similar properties. Naturally occurring variants are highlighted with grey boxes. Alternatively spliced regions are underlined. Amino acid residue numbers are shown on the left and right of each sequence and the UniProt accession number and gene name of each sequence are shown to the right of each sequence.
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