Schematic diagram of PSMB8 showing the location of known polymorphisms. (a) Diagram of PSMB8 showing exon organization (drawn to relative scale), location of alternative spliced region, propeptide region that is removed in the mature form of the protein, location of disease causing polymorphisms’, and location of other known polymorphisms. (b) Tertiary structure of 5i (PSMB8) showing polymorphisms (shown in blue) associated with diseases. Structure created using PyMol (http://pymol.org/).
