Review Article

Genetics of Proteasome Diseases

Figure 8

Sequence alignment of human PSMB8 from different animals. Protein sequences of Rattus norvegicus (rat), Bos taurus (bovine), Canis familiaris (dog), Mus musculus (mouse), Homo sapiens (human), Danio rerio (Zebrafish), Felis catus (Cat), Xenopus tropicalis (western clawed frog), Ornithorhynchus anatinus (Duckbill platypus), Xenopus laevis (African clawed frog), and Equus caballus (Horse) PSMB8 were aligned using Clustal W. , identical residue in all six subunits;  :, conserved amino acids with strongly similar properties;  ., conservation between residues of weakly similar properties. Naturally occurring variants are highlighted with grey boxes. Alternatively spliced regions are underlined. Amino acid residue numbers are shown on the left and right of each sequence and the UniProt accession number is also shown.
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