Mammalian Tribbles Homologs at the Crossroads of Endoplasmic Reticulum Stress and Mammalian Target of Rapamycin Pathways

Figure 1

The basic protein structure of TRB isoforms. There is significant sequence divergence in the N-terminal domain among tribbles homologs. The pseudokinase domain has what is believed to be a kinase-dead catalytic loop [26], and the C-terminal domain has MEK1 (binds MAPKK, [44]) and COP1 (binds ubiquitin ligases) binding motifs. The pseudokinase domain is important for protein-protein interactions between transcription factors.