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Volume 2014, Article ID 194185, 6 pages
Review Article

Development of the Rat Model of Lapatinib-Induced Diarrhoea

School of Medical Sciences, University of Adelaide, Frome Road, Adelaide, SA 5005, Australia

Received 25 December 2013; Revised 22 June 2014; Accepted 24 June 2014; Published 7 July 2014

Academic Editor: Marcella Mottolese

Copyright © 2014 Joanne M. Bowen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Targeted therapy of cancer is often associated with clinically significant diarrhoea; however, the mechanisms underpinning this adverse effect are currently unknown. Diarrhoea following treatment with tyrosine kinase inhibitors (TKIs) of EGFR is particularly troublesome. Until recently, understanding of EGFR TKI-induced diarrhoea has been limited to clinical observation. However, our group has recently developed the first rat model of EGFR TKI-induced diarrhoea. This paper reviews the published and unpublished findings.