Table of Contents Author Guidelines Submit a Manuscript
Scientifica
Volume 2014, Article ID 581639, 29 pages
http://dx.doi.org/10.1155/2014/581639
Review Article

Phage Therapy: Eco-Physiological Pharmacology

Department of Microbiology, The Ohio State University, Mansfield, OH 44906, USA

Received 18 November 2013; Accepted 10 February 2014; Published 20 May 2014

Academic Editors: J. R. Blazquez, M. A. Choudhry, and L. Zhang

Copyright © 2014 Stephen T. Abedon. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bacterial virus use as antibacterial agents, in the guise of what is commonly known as phage therapy, is an inherently physiological, ecological, and also pharmacological process. Physiologically we can consider metabolic properties of phage infections of bacteria and variation in those properties as a function of preexisting bacterial states. In addition, there are patient responses to pathogenesis, patient responses to phage infections of pathogens, and also patient responses to phage virions alone. Ecologically, we can consider phage propagation, densities, distribution (within bodies), impact on body-associated microbiota (as ecological communities), and modification of the functioning of body “ecosystems” more generally. These ecological and physiological components in many ways represent different perspectives on otherwise equivalent phenomena. Comparable to drugs, one also can view phages during phage therapy in pharmacological terms. The relatively unique status of phages within the context of phage therapy as essentially replicating antimicrobials can therefore result in a confluence of perspectives, many of which can be useful towards gaining a better mechanistic appreciation of phage therapy, as I consider here. Pharmacology more generally may be viewed as a discipline that lies at an interface between organism-associated phenomena, as considered by physiology, and environmental interactions as considered by ecology.