Figure 1: Results from a randomized controlled study on effects of replacement therapy versus conventional treatment on plasma ionized calcium levels. Patients in the placebo group received placebo injections in combination with conventional therapy (calcium supplements and activated vitamin D analogues). Data are stratified by whether patients at the end of study were managed on treatment with PTH alone (PTH only), PTH plus activated vitamin D (PTH + VitD), PTH plus activated vitamin D and calcium supplements (PTH + VitD + calcium), or placebo. The background light gray square indicates the reference range (1.18–1.32 mmol/l). Reproduced with permission from JBMR [17].