The Cardioprotective Actions of Hydrogen Sulfide in Acute Myocardial Infarction and Heart Failure
Figure 1
History of the emergence of hydrogen sulfide (H2S) as a physiological regulator of cardiovascular homeostasis. H2S is believed to be responsible for mass extinctions that occurred over 250 million years ago as toxic gases were spewed from deep in the earth. In the 1700s, H2S was linked to injuries sustained by sewer workers. In 1989, H2S was detected in the brain of mammals by several groups. In 1996-1997, H2S was shown to modulate vascular tone and neuronal function. Finally in 2002, H2S was implicated in vascular function and blood pressure regulation in seminal studies. H2S was then shown to posttranslationally modify proteins via s-sulfhydration by Dr. Sol Snyder’s group. Adopted from Hideo Kimura, Ph.D. Ward [71], Savage and Gould [72], Goodwin et al. [73], Warenycia et al. [74], and Mustafa et al. [75].
