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Scientifica
Volume 2014, Article ID 821969, 17 pages
http://dx.doi.org/10.1155/2014/821969
Review Article

Invasive Mold Infections in Solid Organ Transplant Recipients

1Université Paris Descartes, Sorbonne Paris Cité, Centre d’Infectiologie Necker Pasteur, Institut Imagine, Hôpital Universitaire Necker-Enfants Malades, APHP, 75015 Paris, France
2Institut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycoses Invasives et Antifongiques, CNRS URA3012, 75015 Paris, France

Received 4 August 2014; Accepted 3 November 2014; Published 23 November 2014

Academic Editor: Maurizio Sanguinetti

Copyright © 2014 Yoann Crabol and Olivier Lortholary. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Invasive mold infections represent an increasing source of morbidity and mortality in solid organ transplant recipients. Whereas there is a large literature regarding invasive molds infections in hematopoietic stem cell transplants, data in solid organ transplants are scarcer. In this comprehensive review, we focused on invasive mold infection in the specific population of solid organ transplant. We highlighted epidemiology and specific risk factors for these infections and we assessed the main clinical and imaging findings by fungi and by type of solid organ transplant. Finally, we attempted to summarize the diagnostic strategy for detection of these fungi and tried to give an overview of the current prophylaxis treatments and outcomes of these infections in solid organ transplant recipients.