Table of Contents Author Guidelines Submit a Manuscript
Scientifica
Volume 2014, Article ID 903014, 9 pages
http://dx.doi.org/10.1155/2014/903014
Review Article

XB130—A Novel Adaptor Protein: Gene, Function, and Roles in Tumorigenesis

1Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, ON, Canada M5G 1L7
2Department of Physiology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON, Canada M5S 1A8
3Institute of Medical Science, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON, Canada M5S 1A8
4Department of Surgery, Faculty of Medicine, University of Toronto, 149 College Street, Toronto, ON, Canada M5T 1P5

Received 10 February 2014; Accepted 15 May 2014; Published 5 June 2014

Academic Editor: Patrick Auberger

Copyright © 2014 Xiao-Hui Bai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Wallez, P. D. Mace, E. B. Pasquale, and S. J. Riedl, “NSP-CAS protein complexes: emerging signaling modules in cancer,” Genes and Cancer, vol. 3, no. 5-6, pp. 382–393, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Gery and H. P. Koeffler, “Role of the adaptor protein LNK in normal and malignant hematopoiesis,” Oncogene, vol. 32, no. 26, pp. 3111–3118, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Pawson and J. D. Scott, “Signaling through scaffold, anchoring, and adaptor proteins,” Science, vol. 278, no. 5346, pp. 2075–2080, 1997. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Xu, X.-H. Bai, M. Lodyga et al., “XB130, a novel adaptor protein for signal transduction,” The Journal of Biological Chemistry, vol. 282, no. 22, pp. 16401–16412, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. B. N. Snyder, Y. Cho, Y. Qian, J. E. Coad, D. C. Flynn, and J. M. Cunnick, “AFAP1L1 is a novel adaptor protein of the AFAP family that interacts with cortactin and localizes to invadosomes,” European Journal of Cell Biology, vol. 90, no. 5, pp. 376–389, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Nagase, R. Kikuno, and O. Ohara, “Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins,” DNA Research, vol. 8, no. 4, pp. 179–187, 2001. View at Google Scholar · View at Scopus
  7. D. Yamanaka, T. Akama, T. Fukushima et al., “Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells,” Molecular Endocrinology, vol. 26, no. 6, pp. 1043–1055, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Stelzer, I. Dalah, T. I. Stein et al., “In-silico human genomics with GeneCards,” Human Genomics, vol. 5, no. 6, pp. 709–717, 2011. View at Google Scholar · View at Scopus
  9. J. M. Gebauer, S. Müller, F.-G. Hanisch, M. Paulsson, and R. Wagener, “O-Glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO (VWA2 protein),” The Journal of Biological Chemistry, vol. 283, no. 26, pp. 17846–17854, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. A. C. Kim, L. L. Peters, J. H. M. Knoll et al., “Limatin (LIMAB1), an actin-binding LIM protein, maps to mouse chromosome 19 and human chromosome 10q25, a region frequently deleted in human cancers,” Genomics, vol. 46, no. 2, pp. 291–293, 1997. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Flicek, M. R. Amode, D. Barrell et al., “Ensembl 2014,” Nucleic Acids Research, vol. 42, pp. D749–D755, 2014. View at Google Scholar
  12. M. Lodyga, V. de Falco, X.-H. Bai et al., “XB130, a tissue-specific adaptor protein that couples the RET/PTC oncogenic kinase to PI 3-kinase pathway,” Oncogene, vol. 28, no. 7, pp. 937–949, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Uhlen, P. Oksvold, L. Fagerberg et al., “Towards a knowledge-based human protein atlas,” Nature Biotechnology, vol. 28, no. 12, pp. 1248–1250, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Shiozaki, M. Lodyga, X.-H. Bai et al., “XB130, a novel adaptor protein, promotes thyroid tumor growth,” American Journal of Pathology, vol. 178, no. 1, pp. 391–401, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Shiozaki, T. Kosuga, D. Ichikawa et al., “XB130 as an independent prognostic factor in human esophageal squamous cell carcinoma,” Annals of Surgical Oncology, vol. 20, no. 9, pp. 3140–3150, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Shi, W. Huang, L. Lin et al., “Silencing of XB130 is associated with both the prognosis and chemosensitivity of gastric cancer,” PLoS ONE, vol. 7, no. 8, Article ID e41660, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. J. M. Baisden, Y. Qian, H. M. Zot, and D. C. Flynn, “The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity,” Oncogene, vol. 20, no. 44, pp. 6435–6447, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. B. Han, X.-H. Bai, M. Lodyga et al., “Conversion of mechanical force into biochemical signaling,” The Journal of Biological Chemistry, vol. 279, no. 52, pp. 54793–54801, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Lodyga, X.-H. Bai, A. Kapus, and M. Liu, “Adaptor protein XB130 is a Rac-controlled component of lamellipodia that regulates cell motility and invasion,” Journal of Cell Science, vol. 123, no. 23, pp. 4156–4169, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Okutani, M. Lodyga, B. Han, and M. Liu, “Src protein tyrosine kinase family and acute inflammatory responses,” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 291, no. 2, pp. L129–L141, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Shiozaki, G. Shen-Tu, X. Bai et al., “XB130 mediates cancer cell proliferation and survival through multiple signaling events downstream of Akt,” PLoS ONE, vol. 7, no. 8, Article ID e43646, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Emaduddin, M. J. Edelmann, B. M. Kessler, and S. M. Feller, “Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells,” Cell Communication and Signaling, vol. 6, article 7, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. S. A. Courtneidge, “Role of Src in signal transduction pathways. The Jubilee Lecture,” Biochemical Society Transactions, vol. 30, no. 2, pp. 11–17, 2002. View at Google Scholar · View at Scopus
  24. A. Boureux, O. Furstoss, V. Simon, and S. Roche, “Abl tyrosine kinase regulates a Rac/JNK and a Rac/Nox pathway for DNA synthesis and Myc expression induced by growth factors,” Journal of Cell Science, vol. 118, no. 16, pp. 3717–3726, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. G. S. Martin, “The hunting of the Src,” Nature Reviews Molecular Cell Biology, vol. 2, pp. 467–475, 2001. View at Publisher · View at Google Scholar
  26. J.-T. Kim and C.-K. Joo, “Involvement of cell-cell interactions in the rapid stimulation of Cas tyrosine phosphorylation and Src kinase activity by transforming growth factor-β1,” The Journal of Biological Chemistry, vol. 277, no. 35, pp. 31938–31948, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Khanjani, V. Terzidou, M. R. Johnson, and P. R. Bennett, “NFκB and AP-1 drive human myometrial IL8 expression,” Mediators of Inflammation, vol. 2012, Article ID 504952, 8 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. Y.-R. Kim, H. S. Sun, M. Won et al., “Modulatory role of phospholipase D in the activation of signal transducer and activator of transcription (STAT)-3 by thyroid oncogenic kinase RET/PTC,” BMC Cancer, vol. 8, article 144, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. K. S. Saini, S. Loi, E. de Azambuja et al., “Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer,” Cancer Treatment Reviews, vol. 39, no. 8, pp. 935–946, 2013. View at Publisher · View at Google Scholar
  30. J. Ma, H. Sawai, Y. Matsuo et al., “IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cells,” Journal of Surgical Research, vol. 160, no. 1, pp. 90–101, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Han, H. Xiao, J. Xu et al., “Actin filament associated protein mediates c-Src related SRE/AP-1 transcriptional activation,” FEBS Letters, vol. 585, no. 3, pp. 471–477, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. B. Ping, X. He, W. Xia et al., “Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKβ overexpression in human breast cancers,” International Journal of Oncology, vol. 29, no. 5, pp. 1103–1110, 2006. View at Google Scholar · View at Scopus
  33. P. S. Tang, M. Mura, R. Seth, and M. Liu, “Acute lung injury and cell death: how many ways can cells die?” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 294, no. 4, pp. L632–L641, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. M. H. Cardone, N. Roy, H. R. Stennicke et al., “Regulation of cell death protease caspase-9 by phosphorylation,” Science, vol. 282, no. 5392, pp. 1318–1321, 1998. View at Google Scholar · View at Scopus
  35. O. W. Rokhlin, N. V. Guseva, A. F. Tagiyev, R. A. Glover, and M. B. Cohen, “Caspase-8 activation is necessary but not sufficient for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in the prostatic carcinoma cell line LNCaP,” Prostate, vol. 52, no. 1, pp. 1–11, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Shiozaki and M. Liu, “Roles of XB130, a novel adaptor protein, in cancer,” Journal of Clinical Bioinformatics, vol. 1, article 10, 2011. View at Publisher · View at Google Scholar
  37. B. Zhang, X. Pan, G. P. Cobb, and T. A. Anderson, “microRNAs as oncogenes and tumor suppressors,” Developmental Biology, vol. 302, no. 1, pp. 1–12, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Thomas, K. Lange-Grünweller, U. Weirauch et al., “The proto-oncogene Pim-1 is a target of miR-33a,” Oncogene, vol. 31, no. 7, pp. 918–928, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. H. Liu, A. R. Brannon, A. R. Reddy et al., “Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell renal cell carcinoma,” BMC Systems Biology, vol. 4, article 51, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. S. Uhlmann, H. Mannsperger, J. D. Zhang et al., “Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer,” Molecular Systems Biology, vol. 8, article 570, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. H. Takeshita, A. Shiozaki, X.-H. Bai et al., “XB130, a new adaptor protein, regulates expression of tumor suppressive microRNAs in cancer cells,” PLoS ONE, vol. 8, no. 3, Article ID e59057, 2013. View at Publisher · View at Google Scholar · View at Scopus
  42. S. Hossain, P. M. Dubielecka, A. F. Sikorski, R. B. Birge, and L. Kotula, “Crk and ABI1: binary molecular switches that regulate abl tyrosine kinase and signaling to the cytoskeleton,” Genes and Cancer, vol. 3, no. 5-6, pp. 402–413, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. M. H. Pauker, B. Reicher, S. Fried, O. Perl, and M. Barda-Saad, “Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization,” Molecular and Cellular Biology, vol. 31, no. 13, pp. 2653–2666, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. L. Rider and M. Diakonova, “Adapter protein sh2b1β binds filamin A to regulate prolactin-dependent cytoskeletal reorganization and cell motility,” Molecular Endocrinology, vol. 25, no. 7, pp. 1231–1243, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. Á. Lányi, M. Baráth, Z. Péterfi et al., “The homolog of the five SH3-domain protein (HOFI/SH3PXD2B) regulates lamellipodia formation and cell spreading,” PLoS ONE, vol. 6, no. 8, Article ID e23653, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. H. Xiao, B. Han, M. Lodyga, X.-H. Bai, Y. Wang, and M. Liu, “The actin-binding domain of actin filament-associated protein (AFAP) is involved in the regulation of cytoskeletal structure,” Cellular and Molecular Life Sciences, vol. 69, no. 7, pp. 1137–1151, 2012. View at Publisher · View at Google Scholar · View at Scopus
  47. H. Zhang, C.-J. Duan, W. Chen et al., “Clinical significance of SH2B1 adaptor protein expression in non-small cell lung cancer,” Asian Pacific Journal of Cancer Prevention, vol. 13, no. 5, pp. 2355–2362, 2012. View at Publisher · View at Google Scholar · View at Scopus
  48. J. Zhang, I. P. Serk, M. C. Artime et al., “AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts,” The Journal of Clinical Investigation, vol. 117, no. 10, pp. 2962–2973, 2007. View at Publisher · View at Google Scholar · View at Scopus
  49. A. Dorfleutner, C. Stehlik, J. Zhang, G. E. Gallick, and D. C. Flynn, “AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells,” Journal of Cellular Physiology, vol. 213, no. 3, pp. 740–749, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. M. Furu, Y. Kajita, S. Nagayama et al., “Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas,” Oncogene, vol. 30, no. 38, pp. 4015–4025, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. Y. Kajita, T. Kato Jr., S. Tamaki et al., “The transcription factor Sp3 regulates the expression of a metastasis-related marker of sarcoma, actin filament-associated protein 1-like 1 (AFAP1L1),” PLoS ONE, vol. 8, no. 1, Article ID e49709, 2013. View at Publisher · View at Google Scholar · View at Scopus
  52. I. W. Cunha, K. C. Carvalho, W. K. Martins et al., “Identification of genes associated with local aggressiveness and metastatic behavior in soft tissue tumors,” Translational Oncology, vol. 3, no. 1, pp. 23–32, 2010. View at Publisher · View at Google Scholar · View at Scopus
  53. Q. Zuo, H. Huang, M. Shi et al., “Multivariate analysis of several molecular markers and clinicopathological features in postoperative prognosis of hepatocellular carcinoma,” Anatomical Record, vol. 295, no. 3, pp. 423–431, 2012. View at Publisher · View at Google Scholar · View at Scopus
  54. R. E. Mebius and G. Kraal, “Structure and function of the spleen,” Nature Reviews Immunology, vol. 5, no. 8, pp. 606–616, 2005. View at Publisher · View at Google Scholar · View at Scopus