Exogenous Pulmonary Surfactant as a Vehicle for Antimicrobials: Assessment of Surfactant-Antibacterial Interactions In Vitro

Table 3

Bacteriostatic and bactericidal characteristics of antibiotic solutions and experimental surfactant/antibacterial mixtures.

Antibiotics and antibiotic/surfactant compositions	MIC and MBC data (mg/L)
	S. aureus		K. pneumoniae		P. aeruginosa
	MIC	MBC	MIC	MBC	MIC	MBC
Amikacin	3.9	3.9	1.9	1.9	3.9	3.9
Amikacin + surfactant	3.9	3.9	1.9	1.9	3.9	3.9
Cefepime	≤0.49	1.9	>1,000	>1,000	3.9	500
Cefepime + surfactant	≤0.49	3.9	>1,000	>1,000	3.9 (1.9)	1,000
Colistimethate sodium	80	80	20	160	20	160
Colistimethate sodium + surfactant	20	80	20 (10)	160	10	160

Notes: MBC: minimum bactericidal concentration; MIC: minimum inhibitory concentration. Additional MIC values are presented in round parentheses when different results were obtained for distinct replications.