Example of CYP2A6 gene variants structures and related enzymatic activities in nicotine metabolism.
|CYP2A6 gene variants||Nucleotide change||Protein alteration||Enzymatic activities|
|CYP2A*1A (wild type)||None||None||Normal|
|CYP2A6*1H ||-745A>G||Disruption of CCAAT box||Decrease|
|CYP2A6*4A ||CYP2A6 deleted||No produced protein||None|
|CYP2A6*9A ||-1013A>G, -48T>G; 51G>A||Change in TATA box||Decrease|
|CYP2A6*12A ||Change Exon 3–8 of CYP2A6 origin||10 amino acid substitution||Decrease|
|Note: change in the nucleotide of these gene variants alters or inhibits their enzymatic activities decreasing their nicotine metabolism activities in comparison with CYP2A6*1A (wild type) gene variants . |