Scientifica / 2015 / Article / Tab 1

Review Article

CYP2A6 Polymorphisms May Strengthen Individualized Treatment for Nicotine Dependence

Table 1

Example of CYP2A6 gene variants structures and related enzymatic activities in nicotine metabolism.

CYP2A6 gene variantsNucleotide changeProtein alterationEnzymatic activities

CYP2A*1A (wild type)NoneNoneNormal
CYP2A6*1H -745A>GDisruption of CCAAT boxDecrease
CYP2A6*4A CYP2A6 deletedNo produced proteinNone
CYP2A6*9A -1013A>G, -48T>G; 51G>AChange in TATA boxDecrease
CYP2A6*12A Change Exon 3–8 of CYP2A6 origin10 amino acid substitutionDecrease

Note: change in the nucleotide of these gene variants alters or inhibits their enzymatic activities decreasing their nicotine metabolism activities in comparison with CYP2A6*1A (wild type) gene variants [22].

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