Scientifica / 2015 / Article / Tab 2

Review Article

CYP2A6 Polymorphisms May Strengthen Individualized Treatment for Nicotine Dependence

Table 2

Estimates of CYP2A6 gene variants nicotine metabolizer activities.

Metabolizer groupsEstimates enzymatic activitiesGenotype descriptions

Normal metabolizer (NM)100% nicotine metabolismNo loss of alleles function detected CYP2A6*1A
Slow metabolizers (SM)(1) Less than 50% of nicotine metabolism activitiesLess than 1/0 allele loss-of-function.
Examples: CYP2A*2 & *4
(2) Nearly 75% of nicotine metabolism activities1 allele loss-of-function
Examples: CYP2A*9 & *12

Note. In general, gene variant decreases enzymatic activities due to their loss-of-functions [3, 22].

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