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Scientifica
Volume 2015 (2015), Article ID 732438, 8 pages
http://dx.doi.org/10.1155/2015/732438
Review Article

Potential Use of Natural Killer Cell Transfer Therapy in the Perioperative Period to Improve Oncologic Outcomes

1Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
2Anesthesiology and Surgical Oncology Research Group, Houston, TX, USA
3Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
4Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA

Received 1 June 2015; Accepted 5 October 2015

Academic Editor: Mariolina Salio

Copyright © 2015 Juan P. Cata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Immune suppression after oncologic surgery is a common phenomenon. Several studies have demonstrated that it is associated with poor survival owing to cancer progression. Immunotherapy, especially NK cell transfer therapy, is an attractive alternative because current methodologies to isolate, generate, and expand NK cells have shown good safety profiles in current active investigations. We believe that the use of NK cell transfer therapy in the context of postoperative minimal residual disease deserves significant investigation.