Scientifica / 2016 / Article / Tab 1 / Review Article
The Impact of Evolutionary Driving Forces on Human Complex Diseases: A Population Genetics Approach Table 1 Description of natural selection signature on complex diseases in human populations.
Disease Studied population FST value References Blood pressure European populations (CEU, GBR, TSI, FIN) (EUR) 0.0022 (SBP) 0.0054 (DBP) [63 ] Blood pressure European, non-European (Africans and Asians) rs3184504 = 0.0042 [63 ] Systemic lupus erythematosus African, Asian, European Global = 0.008 AFR-EUR = 0.0028 Eurasia split = 0.001 [63 , 64 ] Type 2 diabetes African, Asian, European Global = 0.0354 [63 , 123 ] Coronary heart disease African and European AFR-EUR = 0.034 [63 , 65 ] Prostate cancer African, Asian, European Global = 0.017 AFR = 0.0002 [67 , 68 ] Colorectal cancer Asian populations ASN = 0.0006 [63 ]
CEU: Utah Residents with Northern and Western European ancestry, GBR: British in England and Scotland, TSI: Toscani in Italia, FIN: Finnish in Finland, EUR: European all SNPs FST value, SBP: systolic blood pressure, DBP: diastolic blood pressure, and AFR: African.