The Impact of Evolutionary Driving Forces on Human Complex Diseases: A Population Genetics Approach

Table 1

Description of natural selection signature on complex diseases in human populations.

Disease	Studied population	FST value	References
Blood pressure	European populations (CEU, GBR, TSI, FIN)	(EUR); 0.0022 (SBP); 0.0054 (DBP)	[63]
Blood pressure	European, non-European (Africans and Asians)	rs3184504 = 0.0042	[63]
Systemic lupus erythematosus	African, Asian, European	Global = 0.008; AFR-EUR = 0.0028; Eurasia split = 0.001	[63, 64]
Type 2 diabetes	African, Asian, European	Global = 0.0354	[63, 123]
Coronary heart disease	African and European	AFR-EUR = 0.034	[63, 65]
Prostate cancer	African, Asian, European	Global = 0.017; AFR = 0.0002	[67, 68]
Colorectal cancer	Asian populations	ASN = 0.0006	[63]

CEU: Utah Residents with Northern and Western European ancestry, GBR: British in England and Scotland, TSI: Toscani in Italia, FIN: Finnish in Finland, EUR: European all SNPs FST value, SBP: systolic blood pressure, DBP: diastolic blood pressure, and AFR: African.