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Volume 2016, Article ID 2683403, 7 pages
Research Article

Safety Evaluation of Unani Formulation: Capsule Shaqeeqa in Albino Wistar Rats

1Drug Standardisation Research Unit, Regional Research Institute of Unani Medicine, CCRUM, University of Kashmir, Naseem Bagh Campus, Srinagar 190006, India
2Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir 190006, India
3Central Council for Research in Unani Medicine, New Delhi 110058, India

Received 30 December 2015; Revised 7 March 2016; Accepted 16 March 2016

Academic Editor: Evan P. Cherniack

Copyright © 2016 Khalid Ghazanfar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Capsule Shaqeeqa, Unani formulation, is prescribed for the clinical treatment of diseases like sinusitis, headache, and migraine. The safety evaluation data of it is not available; in order to provide the safety data the present study was carried out. The study was carried out on four groups of rats (). Two groups (one male and one female group) as normal controls were orally given water while the other two groups were orally given daily doses of drug at the dose level of 150 mg/kg of body weight for duration of 90 days. Physiological parameters like body weight, feed consumption, water consumption, and clinical signs were regularly monitored and recorded. Organs were collected, examined, and weighed and specimens were taken for histopathological studies. The results showed that the drug did not alter the physiological parameters. There was no mortality or any morbidity found in drug treated rats. There was no statistical significant change found in any haematological or biochemical parameter of rats orally fed with Shaqeeqa. A statistically insignificant association verified that haematological and biochemical parameters were rendered unaffected by the drug. Moreover histological investigations of essential key organs demonstrated that the drug did not prompt any histopathological change. These observations demonstrate the safety of Capsule Shaqeeqa at the studied dosage levels.