Extract of Sesbania grandiflora Ameliorates Hyperglycemia in High Fat Diet-Streptozotocin Induced Experimental Diabetes Mellitus
Table 4
Effect of MESG on serum parameters during end of the drug treatment period.
Serum parameters
Group I Normal control
Group II Diabetic control
Group III Metformin treated
Group IV 200 mg/kg MESG treated
Group V 400 mg/kg MESG treated
Total cholesterol
59.33 ± 4.03
166.50 ± 5.01
82.67 ± 4.57
122.17 ± 5.53
102.17 ± 4.83
Triglycerides
53.83 ± 3.93
147.67 ± 5.16
71.50 ± 3.55
114.83 ± 3.10
88.83 ± 3.74
HDL
29.17 ± 1.66
16.50 ± 1.63
27.67 ± 2.11
22.17 ± 1.85
24.33 ± 2.20
LDL
19.40 ± 4.07
120.47 ± 7.02
40.70 ± 4.91
77.03 ± 6.29
60.07 ± 4.33
VLDL
10.77 ± 0.79
29.53 ± 1.03
14.30 ± 0.71
22.97 ± 0.62
17.77 ± 0.75
SGOT (U/L)
41.17 ± 1.30
72.33 ± 2.51
52.17 ± 1.87
62.33 ± 2.17
57.83 ± 2.61
SGPT (U/L)
38.83 ± 2.65
89.17 ± 2.69
47.33 ± 2.94
68.17 ± 3.71
54.83 ± 3.21
Creatinine (mg/dL)
0.54 ± 0.06
1.50 ± 0.07
0.68 ± 0.05
1.13 ± 0.08
0.87 ± 0.07
Serum urea (mg/dL)
33.17 ± 2.09
70.33 ± 3.39
38.83 ± 3.10
57.17 ± 3.56
49.83 ± 3.74
Serum protein (gm/dL)
6.72 ± 0.32
3.47 ± 0.30
6.35 ± 0.37
5.05 ± 0.37
5.90 ± 0.33
Serum SOD (U/mL)
31.73 ± 1.18
19.92 ± 1.26
28.83 ± 1.10
25.78 ± 1.24
27.17 ± 1.31
Serum MDA (nmole/mL)
6.23 ± 0.62
14.28 ± 1.04
7.67 ± 0.85
10.78 ± 0.70
8.85 ± 0.76
The results were expressed as mean ± SEM, . ; diabetic control versus normal control. , , and , metformin treated and MESG treated groups versus diabetic control group. “#” indicates that there is no significant difference between metformin treated and MESG treated groups at .
