Development and Validation of Stability-Indicating Method for Estimation of Chlorthalidone in Bulk and Tablets with the Use of Experimental Design in Forced Degradation Experiments

Table 2

(a) Yates analysis and ANOVA for acid degradation. (b) Yates analysis and ANOVA for alkali degradation.

(a)

Expt.	(response)				Effect	Mean square	value
(1)	7	12	55	146	—	—	—
(2)	5	43	91	−6	−1.5	4.5	18
(3) ()	23	20	−5	82	20.5	840.5	3360
(4) ()	20	71	−1	−2	−0.5	0.5	2
(5)	10	−2	31	36	9	162	648
(6)	10	−3	51	4	1	2	8
(7)	36	0	−1	20	5	50	200
(8)	35	−1	−1	0	0	0	0

(b)

Expt.	(response)				Effect	Mean square	value
(1)	5	13	66	156	—	—	—
(2)	8	53	90	8	2	8	2.46
(3)	25	22	6	86	21.5	924.5	284.46
(4)	28	68	2	6	1.5	4.5	1.38
(5)	12	3	40	24	6	72	22.2
(6)	10	3	46	−4	−1	2	0.62
(7)	32	−2	0	6	1.5	4.5	1.38
(8) ()	36	4	6	6	1.5	4.5	1.38