Development and Validation of Stability-Indicating Method for Estimation of Chlorthalidone in Bulk and Tablets with the Use of Experimental Design in Forced Degradation Experiments

Table 5

Accuracy and precision studies.

Amount added (mg)	Amount found (mg)			Within mean square	Between mean square	value
	Day 1	Day 2	Day 3
80% (10 mg)	10	10.02	10	0.0009	0.00028	0.3086
	10.05	10.03	10.09
	10.03	10.03	10.04
Mean	10.03	10.03	10.04
SD	0.252	0.058	0.451
% RSD	0.251	0.058	0.449
100% (12.5 mg)	12.45	12.42	12.45	0.00208	0.00174	0.8396
	12.42	12.41	12.42
	12.33	12.49	12.46
Mean	12.4	12.44	12.44
SD	0.62	0.44	0.208
% RSD	0.503	0.350	0.167
120% (15 mg)	14.09	14.01	14.032	0.00078	0.0012	1.508
	14.02	14.03	14.07
	14.06	14.04	14.09
Mean	14.06	14.03	14.06
SD	0.351	0.152	0.295
% RSD	0.251	0.110	0.209