Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats
Table 2
The effect of gentamicin (GM) on the serum levels of blood urea nitrogen (BUN), creatinine (Cr), malondialdehyde (MDA), kidney level of MDA, kidney tissue damage score (KTDS), body weight change (BW), kidney weight (KW), and uterus weight (UW) in male and female rats.
Gender
Group
BUN (mg/dL)
Cr (mg/dL)
Serum MDA (mole/L)
Kidney MDA (nmole/g tissue)
KTDS
KW (g/100 g BW)
UW (g/100 g BW)
BW (g)
Female
Control (group 1)
21.79 ± 1.07
0.52 ± 0.08
5.49 ± 1.87
2.77 ± 0.20
0.33 ± 0.21
0.76 ± 0.02
0.02 ± 0.00
8.66 ± 1.68
GM (group 2)
38.57 ± 5.67
0.76 ± 0.10
6.83 ± 2.38
6.03 ± 1.10
1.8 ± 0.48
0.84 ± 0.04
0.01 ± 0.00
1.4 ± 2.48
Male
Control (group 10)
23.70 ± 2.39
0.59 ± 0.04
11.65 ± 1.20
2.12 ± 0.20
0.5 ± 0.28
0.74 ± 0.04
—
7.25 ± 6.36
GM (group 11)
34.27 ± 3.43
0.87 ± 0.09
6.88 ± 1.76
7.99 ± 2.23
1.2 ± 0.2
0.85 ± 0.07
—
1.8 ± 2.65
indicates significant difference from control group in each gender ().
