A High-Fat, High-Fructose Diet Induces Antioxidant Imbalance and Increases the Risk and Progression of Nonalcoholic Fatty Liver Disease in Mice

Figure 7

Effects of a high-fat, high-fructose diet on the SOD, CAT, and GPx enzymatic activity in the mouse brains. Mice were fed a commercial standard diet for 4 weeks, and a high-fat, high-fructose diet (HFFD) was administered intragastrically for 2, 4, or 8 weeks. The mice were sacrificed 24 h after the last treatment, and their brains were immediately excised to determine the SOD, CAT, and GPx enzyme activities. The data are presented as the mean ± SD (). Significant differences were determined using a one-way analysis of variance (ANOVA) followed by Tukey’s post hoc test. versus the regular diet mice.

(a) SOD

(b) CAT

(c) GPx