A High-Fat, High-Fructose Diet Induces Antioxidant Imbalance and Increases the Risk and Progression of Nonalcoholic Fatty Liver Disease in Mice

Figure 9

Effects of a high-fat, high-fructose diet on lipid peroxidation in the mouse brains. Mice were fed a commercial standard diet for 4 weeks, and a high-fat, high-fructose diet (HFFD) was administered intragastrically for 2, 4, or 8 weeks. The mice were sacrificed 24 h after the last treatment, and their brains were immediately excised to determine the levels of malondialdehyde (MDA). The data are presented as the mean ± SD (). Significant differences were determined using a one-way analysis of variance (ANOVA) followed by Tukey’s post hoc test. versus the regular diet mice.