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Scientifica
Volume 2016, Article ID 5823013, 8 pages
http://dx.doi.org/10.1155/2016/5823013
Research Article

Broad Spectrum Anti-Quorum Sensing Activity of Tannin-Rich Crude Extracts of Indian Medicinal Plants

1Department of Microbiology, Ramnarain Ruia College, Matunga, Mumbai 400019, India
2Department of Microbiology, Bhavan’s College, Andheri, Mumbai 400058, India

Received 25 December 2015; Revised 9 March 2016; Accepted 20 March 2016

Academic Editor: Giuseppe Comi

Copyright © 2016 Varsha Shukla and Zarine Bhathena. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Quorum sensing (QS) mechanisms have been demonstrated to have significance in expression of pathogenicity in infectious bacteria. In Gram negative bacteria the autoinducer molecules that mediate QS are acyl homoserine lactones (AHL) and in Gram positive bacteria they are peptides called autoinducing peptides (AIP). A screening of tannin-rich medicinal plants was attempted to identify extracts that could interrupt the QS mechanisms in both Gram positive and Gram negative bacteria over a wide range of concentrations and therefore potentially be potent agents that could act as broad spectrum QS inhibitors. Six out of the twelve Indian medicinal plant extracts that were analyzed exhibited anti-QS activity in Chromobacterium violaceum 12472 and in S. aureus strain with agr:blaZ fusion over a broad range of subinhibitory concentrations, indicating that the extracts contain high concentration of molecules that can interfere with the QS mechanisms mediated by AHL as well as AIP.