DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics

Table 1

DNMT inhibitors in cancer.

Drug	Therapeutic use	Developmental stage
Nucleoside analogue inhibitors
() 5-azacytidine	Myelodysplastic syndrome	Approved [United States-Food and Drug Administration (US-FDA)]
	Acute myeloid leukemia	Phase 2
	Solid tumors	Phase 2
() Decitabine	Myelodysplastic syndrome	Approved (US-FDA)
	Acute myeloid leukemia	Approved [European Commission (EC)]
() Zebularine	Solid tumors like breast, urinary bladder, hepatocellular cancer	Preclinical
() SGI-110	Myelodysplastic syndrome	Phase 1
	Acute myeloid leukemia	Phase 1
	Solid tumors like bladder cancer	Preclinical
Nonnucleoside analogue inhibitors
() Procainamide	Solid tumors like bladder, breast, prostate, cervix	Preclinical
() Procaine
() Epigallocatechin-3-gallate
() SGI-1027	Leukemia	Preclinical
() Hydralazine	Breast cancer	Phase 2
	Ovarian cancer	Phase 3
	Cervical cancer	Phase 3