DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics

Table 2

HDAC inhibitors in developmental phases.

Drug	Therapeutic use	Developmental stage
() Panobinostat	Cutaneous T-cell lymphoma	Phase 3
() Valproic acid	Cervical cancer	Phase 3
	Ovarian cancer	Phase 3
() Belinostat	Ovarian cancer	Phase 2
() Mocetinostat	Follicular lymphoma	Phase 2
	Hodgkin’s lymphoma	Phase 2
	Acute myeloid leukemia	Phase 2
() Abexinostat	Sarcoma and lymphoma	Phase 2
() Entinostat	Hodgkin’s lymphoma	Phase 2
	Breast cancer	Phase 2
	Metastatic lung cancer	Phase 2
() SB939	Prostate cancer	Phase 2
() Resminostat	Hodgkin’s lymphoma	Phase 2
	Hepatocellular carcinoma	Phase 2
() Givinostat	Leukemia and lymphoma	Phase 2
	Myelofibrosis	Preclinical
() Kevetrin	Ovarian cancer	Phase 1
() ACY-1215	Multiple myeloma	Phase 1