Optimization of Thermoreversible In Situ Nasal Gel of Timolol Maleate

Table 3

Formulation of factorial batches.

Sr. number	Ingredient (% w/w)	f1	f2	f3	f4	f5	f6	f7	f8	f9
1	Timolol maleate	1.40	1.418	1.470	1.438	1.449	1.464	1.478	1.484	1.492
2	Poloxamer 407	46	50	54	46	50	54	46	50	54
3	HPMC	0.8	0.8	0.8	1.2	1.2	1.2	1.6	1.6	1.6
4	Distilled water	q.s. up to 100 mL

Note: formulation was determined on weight basis not on volume. The % of drug was calculated and added on the weight basis of the polymer so as to ensure that 1 gm of formulation will contain 10 mg of drug.