Table of Contents Author Guidelines Submit a Manuscript
Scientifica
Volume 2016, Article ID 7623193, 9 pages
http://dx.doi.org/10.1155/2016/7623193
Research Article

Formulation and Pharmacokinetic Evaluation of Microcapsules Containing Pravastatin Sodium Using Rats

1Department of Pharmaceutics & Pharmacology, Acharya and B. M. Reddy College of Pharmacy, Soldevanahalli, Bengaluru 560107, India
2Department of Pharmaceutics, School of Pharmacy, Guru Nanak Institutions Technical Campus, Ibrahimpatnam, Telangana, India

Received 11 December 2015; Revised 3 May 2016; Accepted 8 June 2016

Academic Editor: Roberta Fruttero

Copyright © 2016 Venkatesh Dinnekere Puttegowda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pravastatin Sodium has a cholesterol lowering agent. It has shorter half-life and undergoes first-pass metabolism. Frequent dose is required in case of conventional dosage form. The purpose of the study is to formulate and evaluate microcapsules containing Pravastatin Sodium by complex with cholestyramine resins coated with Eudragit RLPO and Eudragit RSPO polymers for achieving control release. Complexation of drug on resin was carried out by batch method. Microencapsulation was carried out by nonaqueous solvent evaporation method. Pharmacokinetic studies were done by using rats. The intermediate stability studies were carried out on the most satisfactory formulations. FTIR, X-ray diffraction, and DSC spectra of drug, drug-resinates, and polymers revealed no chemical interaction. The % DEE and % yield were observed for formulations of f1 to f7 that were varied from 97.1 ± 0.8 to 98.9 ± 0.5% and 95.0 ± 3.25 to 98.8 ± 7.1%, respectively. Most satisfactory formulation, f6, showed drug release up to 72.6%. No changes in % DEE and % CDR were observed after stability studies. Microcapsules of f6 formulation achieved best performance regarding in vitro drug release and from pharmacokinetic evaluation mean residence time was found to be 6.3 h, thus indicated, Pravastatin Sodium microcapsules were released and absorbed slowly over a prolonged period of time.