Research Article
Formulation and Pharmacokinetic Evaluation of Microcapsules Containing Pravastatin Sodium Using Rats
Table 2
Physicochemical properties of developed formulations.
| | B-code | Drug-resinates to polymer ratio (% w/w) | % yield | Angle of repose (°) | Compressibility index (%) | Bulk density (g/cc) | % DEE | % coating of polymer | Particle size (μm) |
| | f1 | — | 97.0 ± 2.25 | 22.0 | 7.15 | 0.56 | 98.9 ± 0.5 | 97.4 ± 0.6 | 45–198 | | f2 | 10 | 95.1 ± 3.25 | 22.2 | 7.50 | 0.48 | 97.1 ± 0.8 | 97.6 ± 2.6 | 60–199 | | f3 | 20 | 96.3 ± 6.30 | 22.5 | 6.01 | 0.55 | 97.6 ± 0.8 | 97.1 ± 7.8 | 63–242 | | f4 | 30 | 97.9 ± 7.5 | 22.3 | 5.61 | 0.40 | 97.9 ± 0.8 | 98.7 ± 8.9 | 87–323 | | f5 | 10 | 98.1 ± 5.75 | 22.1 | 5.00 | 0.40 | 97.9 ± 0.5 | 97.9 ± 7.6 | 59–205 | | f6 | 20 | 98.8 ± 7.1 | 22.5 | 5.55 | 0.41 | 98.7 ± 0.3 | 98.6 ± 8.8 | 62–214 | | f7 | 30 | 97.4 ± 4.84 | 22.4 | 6.88 | 0.52 | 98.7 ± 0.2 | 98.9 ± 9.7 | 80–344 |
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All the values were average mean of 3 determinations.
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