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Scientifica
Volume 2016, Article ID 8525679, 11 pages
http://dx.doi.org/10.1155/2016/8525679
Review Article

Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs

1School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore, India
2College of Pharmacy, IPS Academy, Indore, India

Received 30 December 2015; Revised 16 March 2016; Accepted 31 March 2016

Academic Editor: Chiara Riganti

Copyright © 2016 Mayank Sharma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Oral administration is the most convenient route among various routes of drug delivery as it offers high patient compliance. However, the poor aqueous solubility and poor enzymatic/metabolic stability of drugs are major limitations in successful oral drug delivery. There are several approaches to improve problems related to hydrophobic drugs. Among various approaches, nanotechnology based drug delivery system has potential to overcome the challenges associated with the oral route of administration. Novel drug delivery systems are available in many areas of medicine. The application of these systems in the treatment of hypertension continues to broaden. The present review focuses on various nanocarriers available in oral drug administration for improving solubility profile, dissolution, and consequently bioavailability of hydrophobic antihypertensive drugs.