Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs

Table 1

Summary of some of the investigations on nanosystems of antihypertensive drugs.

Name of drug	Colloidal system	Application	Ref. number
Carvedilol	Solid lipid nanoparticles	Enhanced bioavailability and protecting it from acidic environment	[25]
	Nanosuspensions	Increased oral bioavailability	[26]
	Carbon nanotubes	Drug loading capacity and improving the solubility	[27]
	Mesoporous silica nanoparticles	Improvement in drug loading and drug release profile
Nebivolol	Polymeric nanoparticles	Prolonged drug release	[28]
Valsartan	Solid lipid nanoparticles	Bypassing first-pass metabolism, enhancing lymphatic absorption, and improving solubility and bioavailability	[29]
	Nanosuspensions	Enhanced drug release	[30]
	Self-nanoemulsifying drug delivery system	Increase in dissolution rate	[31]
	Polymeric nanoparticles	Prolonged release of drug and thereby it decreases its dose size, frequency of dose, and side effects	[32]
	Proliposomes	Good flowability and particle size distribution and well conversion into liposomes by hydration and desirable in vitro drug release	[33]
Felodipine	Nanosuspensions	Enhanced solubility and oral bioavailability	[34]
	Polymeric nanoparticles	Controllable drug release and effective in vitro compatibility	[35]
Nifedipine	Dendrimers	Enhanced water solubility	[36]
	Polymeric nanoparticles	Improved oral bioavailability	[37]
	Nanocrystals	Enhanced dissolution rate	[38]
Candesartan cilexetil	Dendrimers	Improved water solubility	[39]
	Nanosuspension	Improved bioavailability	[40]
	Polymeric micelles	Increased drug loading capacity and drug release	[41]
Nitrendipine	Solid lipid nanoparticles	Enhanced bioavailability	[42]
	Nanoemulsion	Improved therapeutic efficacy and bioavailability	[43]
	Nanocrystals	Improvement in physical stability, in vitro drug release, and bioavailability	[44, 45]